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KMID : 0545120010110061099
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Journal of Microbiology and Biotechnology
2001 Volume.11 No. 6 p.1099 ~ p.1101
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Citrinin Hydrate Inhibits Serotonin N-Acetyltransferase Catalyzing the Conversion of Serotonin to N-Acetylserotonin
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LEE, IN-KYOUNG
YUN, BONG-SIK/KIM, KYONG-TAI/CHOI, BO-HWA/PARK, TAE-JU/KIM, YOUNG-HO/YOO, ICK-DONG
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Abstract
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In an attempt to search for serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) inhibitors from microbial metabolites, we found the culture broth of Penicillium sp. 80722 which showed a strong inhibitory activity against AA-NAT. The active principle has been identified as citrinin hydrate through bioassay-guided fractionation of cultural broth, and structure elucidation derived by spectroscopic analyses. Citrinin hydrate inhibits AA-NAT with an IC_50 value of 173μM in a dose-dependent manner. Although citrinin hydrate was previously isolated as human rhinovirus 3C-protease inhibitor, this was recognized as the first AA-NAT inhibitor isolated from natural sources.
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